Boosting Catheter and Related Systems and Methods

ABSTRACT

The various embodiments herein relate to a boosting catheter for positioning through a conventional guiding catheter into the vasculature of a patient, the boosting catheter having a distal tubular member and a proximal elongated shaft coupled to the distal tubular member.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority as a continuation of U.S. patentapplication Ser. No. 16/188,739, entitled “Boosting Catheter and RelatedSystems and Methods,” filed on Nov. 13, 2018; which claims priority as acontinuation of U.S. Pat. No. 10,124,146, entitled “Boosting Catheterand Related Systems and Methods,” which issued on Nov. 13, 2018; whichclaims priority as a continuation of U.S. Pat. No. 9,144,662, entitled“Boosting Catheter and Related Systems and Methods,” which issued onSep. 29, 2015; which claims priority to U.S. Provisional Application61/793,982, filed Mar. 15, 2013 and entitled “Extension Guide Catheter,”all of which are hereby incorporated herein by reference in theirentireties.

FIELD OF THE INVENTION

The various embodiments disclosed herein relate to guiding catheters foruse as medical devices, and more particularly to boosting catheters foruse with guiding catheter systems.

BACKGROUND OF THE INVENTION

The general use of catheters as medical devices is very well-developedby now. U.S. Pat. No. 4,581,017 to Sahota, for example, shows the use ofa guide catheter for insertion into an artery to assist with treatingthe artery (e.g. with a stenosis); and it further shows the use ofanother catheter for telescoping insertion into the first catheter toextend beyond the first catheter to treat or access portions of theartery that the first catheter cannot reach because of its largerdiameter or lack of flexibility, trackability or support. Subsequentpatents show further developments of such telescoping or extensioncatheter systems. For example, U.S. Pat. No. 5,385,562 to Adams et al.,U.S. Pat. No. 5,439,445 to Kontos, and U.S. Pat. No. 5,290,247 toCrittendon all show the use of a catheter having a tubular portion thatextends or telescopes beyond the guiding catheter, and an elongatedmanipulation/insertion wire or shaft attached to the tubular portion tomanipulate the tubular portion axially—in push/pull fashion—within theguiding catheter after it has been inserted through the hemostasis valveand into the guiding catheter. The Adams '562 patent suggests that theproximal manipulation/insertion wire may actually be a low-diametertubular shaft for conducting air to inflate and deflate a restrictionballoon that restricts movement of the tubular portion.

According to conventional practice with these types of devices, doctorsor technicians often introduce a contrast solution, flushing agent, ortherapeutic agent into and through the guiding catheter in order toassist in the viewing of arteries, veins, and other tissues in the body(e.g. by x-ray or flouroscopy) or for other procedural or therapeuticreasons. In some cases, though, it is desirable to limit the use of suchsolutions because too much of the solution can harm the patient.Introducing the solution through the guiding catheter may result ineither too much solution entering the body or the solution not beinginjected at the correct target location. The diameter of the guidingcatheter must be large enough to conduct a variety of tools and devicesduring the procedure, and so it is not practical to decrease thediameter of the guiding catheter in order to limit the usage of contrastsolution.

Accordingly, there has been a need in the art for improved boostingcatheters and related methods and system.

SUMMARY OF THE INVENTION

Discussed herein are various boosting catheter embodiments for use withstandard guiding catheter.

In Example 1, a boosting catheter comprises a distal tube and a proximalshaft operably coupled to a proximal portion of the distal tube. Thedistal tube comprises a tubular wall and a tube lumen defined within thetube by the tubular wall. The proximal shaft comprises a shaft lumendefined in the proximal shaft, wherein the proximal shaft is configuredto extend distally into a portion of the tube lumen such that the shaftlumen extends distally past a proximal end of the distal tube.

Example 2 relates to the boosting catheter according to Example 1,wherein the proximal shaft further comprises a distal opening in fluidiccommunication with the shaft lumen, whereby the shaft lumen is influidic communication with the tube lumen.

Example 3 relates to the boosting catheter according to Example 2,wherein the shaft lumen is configured to receive fluid such that fluidcan be caused to flow distally through the proximal shaft and out of thedistal opening.

Example 4 relates to the boosting catheter according to Example 2,wherein the proximal shaft is configured to extend distally into aportion of the tubular wall such that the shaft lumen extends distallyinto the tubular wall and such that the distal opening is in fluidiccommunication with the tube lumen.

Example 5 relates to the boosting catheter according Example 2, whereinthe proximal shaft is configured to extend distally into a portion ofthe tubular wall such that the shaft lumen extends distally into thetubular wall and such that the distal opening is in fluidiccommunication with an area external to the distal tube.

Example 6 relates to the boosting catheter according to Example 1,wherein the proximal shaft comprises at least one elongate memberdisposed within the shaft lumen.

Example 7 relates to the boosting catheter according to Example 6,wherein the at least one elongate member defines a lumen within the atleast one elongate member.

Example 8 relates to the boosting catheter according to Example 6,wherein the at least one elongate member has no lumen.

Example 9 relates to the boosting catheter according to Example 6,wherein the at least one elongate member comprises a first elongatemember and a second elongate member, wherein the first elongate memberis configured to extend distally into a first portion of the tubularwall, and further wherein the second elongate member is configured toextend distally into a second portion of the tubular wall.

Example 10 relates to the boosting catheter according to Example 9,further comprising a tube disposed in the proximal shaft.

Example 11 relates to the boosting catheter according to Example 1,further comprising at least one support member disposed in the proximalportion of the distal tube.

Example 12 relates to the boosting catheter according to Example 1,wherein a distal portion of the proximal shaft is at least one supportmember disposed in the proximal portion of the distal tube.

Example 13 relates to the boosting catheter according to Example 1,wherein the shaft lumen is not in fluidic communication with the tubelumen.

Example 14 relates to the boosting catheter according to Example 1,wherein the proximal shaft further comprises a distal opening in fluidiccommunication with an area external to the distal tube.

In Example 15, a method of using a boosting catheter in combination witha standard guiding catheter to perform a procedure at a predeterminedlocation within the vasculature of a patient comprises positioning thestandard guiding catheter into a target vessel in the patient andinserting the boosting catheter into the standard guiding catheter. Themethod further comprises urging the boosting catheter distally throughthe standard guiding catheter such that a distal portion of the distaltube extends distally out of the distal end of the standard guidingcathether. In addition, the method comprises performing a procedurethrough the boosting cathether and standard guiding catheter. Further,the boosting catheter comprises a distal tube and a proximal shaftoperably coupled to a proximal portion of the distal tube. The distaltube comprises a tubular wall and a tube lumen defined within the tubeby the tubular wall. The proximal shaft comprises a shaft lumen definedin the proximal shaft, wherein the proximal shaft is configured toextend distally into a portion of the tube lumen such that the shaftlumen extends distally past a proximal end of the distal tube.

Example 16 relates to the method according to Example 15, wherein theproximal shaft further comprises a distal opening in fluidiccommunication with the shaft lumen, whereby the shaft lumen is influidic communication with the tube lumen.

Example 17 relates to the method according to Example 16, wherein theperforming the procedure further comprises introducing a fluid into theshaft lumen at a proximal end of the proximal shaft, and conducting thefluid distally along the length of the shaft lumen and out of the distalopening.

Example 18 relates to the method according to Example 17, furthercomprising conducting the fluid distally along the length of the guidingcatheter and into the shaft lumen.

Example 19 relates to the method according to Example 15, wherein theperforming the procedure further comprises positioning a medical deviceat the predetermined location through the boosting cathether and guidingcatheter, and performing an interventional, diagnostic, or therapeuticprocedure using the medical device.

Example 20 relates to the method according to Example 15, wherein theperforming the procedure further comprises applying suction at thedistal end of the distal tube to remove thrombus, emboli, or debris atthe predetermined location by applying a vacuum at a proximal end of thestandard guiding catheter.

While multiple embodiments are disclosed, still other embodiments of thepresent invention will become apparent to those skilled in the art fromthe following detailed description, which shows and describesillustrative embodiments of the invention. As will be realized, theinvention is capable of modifications in various obvious aspects, allwithout departing from the spirit and scope of the present invention.Accordingly, the drawings and detailed description are to be regarded asillustrative in nature and not restrictive.

DESCRIPTION OF DRAWINGS

FIG. 1 is an environmental view showing the use of one embodiment of thesubject device in a conventional guiding catheter or sheath, which isused to perform various medical procedures.

FIG. 2A is a closer environmental view showing the distal end of aboosting catheter extending out the end of a conventional guidingcatheter engaged in the coronary vasculature, according to oneembodiment.

FIG. 2B is another environment view showing a boosting catheter in aguiding catheter and including a proximal portion and a distal portion,according to one embodiment.

FIG. 3A is a side view in partial section of a boosting catheter withtwo marker bands, according to one embodiment.

FIG. 3B is a side view in partial section of a boosting catheter withthree marker bands, according to another embodiment.

FIG. 3C is a side view in partial section of a boosting catheter withthree marker bands, according to a further embodiment.

FIG. 4A is a cross-sectional side view showing the proximal shaft of aboosting catheter, according to one embodiment.

FIG. 4B is an end view showing the proximal shaft of FIG. 4A.

FIG. 4C is a top view showing the proximal shaft of FIG. 4A.

FIG. 5 is a cross-sectional side view of the proximal shaft of aboosting catheter, according to another embodiment.

FIG. 6 is a cross-sectional side view of the proximal shaft of aboosting catheter, according to a further embodiment.

FIG. 7A is a top view of a boosting catheter showing the junction of theproximal and distal portions, according to one embodiment.

FIG. 7B is a cross-sectional side view of the boosting catheter of FIG.7A.

FIG. 7C is a cross-sectional end view of the proximal shaft of theboosting catheter of FIG. 7A.

FIG. 8A is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to oneembodiment.

FIG. 8B is a is a perspective view of a portion of the junction of theproximal and distal portions of the boosting catheter of FIG. 8A.

FIG. 9 is a cross-sectional side view of a boosting catheter showing thejunction of the proximal and distal portions, according to anotherembodiment.

FIG. 10 is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to a furtherembodiment.

FIG. 11 is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to yetanother embodiment.

FIG. 12 is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to anotherimplementation.

FIG. 13 is a cross-sectional top view of a proximal shaft of a boostingcatheter, according to one embodiment.

FIG. 14 is a cross-sectional top view of a proximal shaft of a boostingcatheter, according to another embodiment.

FIG. 15A is a cross-sectional view of a proximal shaft of a boostingcatheter, according to a further embodiment.

FIG. 15B is a cross-sectional view of another proximal shaft of aboosting catheter, according to yet another embodiment.

FIG. 16A is a cross-sectional view of a proximal shaft of a boostingcatheter, according to one implementation.

FIG. 16B is a cross-sectional view of a proximal shaft of a boostingcatheter, according to another implementation.

FIG. 16C is a cross-sectional view of a proximal shaft of a boostingcatheter, according to a further implementation.

FIG. 16D is a cross-sectional view of a proximal shaft of a boostingcatheter, according to yet another implementation.

FIG. 16E is a cross-sectional view of a proximal shaft of a boostingcatheter, according to another embodiment.

FIG. 16F is a cross-sectional view of a proximal shaft of a boostingcatheter, according to a further embodiment.

FIG. 16G is a cross-sectional view of a proximal shaft of a boostingcatheter, according to yet another embodiment.

FIG. 16H is a cross-sectional view of a proximal shaft of a boostingcatheter, according to another implementation.

FIG. 16I is a cross-sectional view of a proximal shaft of a boostingcatheter, according to a further implementation.

FIG. 17A is a cross-sectional side view of a proximal shaft of aboosting catheter, according to one embodiment.

FIG. 17B is a cross-sectional side view of a proximal shaft of anotherboosting catheter, according to a further embodiment.

FIG. 18A is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to oneimplementation.

FIG. 18B is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to anotherimplementation.

FIG. 18C is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to a furtherimplementation.

FIG. 19A is a cross-sectional side view of a proximal shaft of aboosting catheter, according to one embodiment.

FIG. 19A′ is an end view of the proximal shaft of the boosting catheterof FIG. 19A.

FIG. 19B is a cross-sectional side view of a proximal shaft of aboosting catheter, according to another embodiment.

FIG. 19C is a cross-sectional side view of a proximal shaft of aboosting catheter, according to a further embodiment.

FIG. 19D is a cross-sectional side view of a proximal shaft of aboosting catheter, according to yet another embodiment.

FIG. 19D′ is a side view of the proximal shaft of the boosting catheterof FIG. 19D, according to one embodiment.

FIG. 19D″ is a side view of the proximal shaft of the boosting catheterof FIG. 19D, according to another embodiment.

FIG. 20A is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to oneimplementation.

FIG. 20B is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to anotherimplementation.

FIG. 20C is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to a furtherimplementation.

FIG. 20D is a perspective view of a boosting catheter showing thejunction of the proximal and distal portions, according to anotherembodiment.

FIG. 21A is a cross-sectional side view of a boosting catheter showingthe junction of the proximal and distal portions, according to oneimplementation.

FIG. 21B is a cross-sectional top view of the boosting catheter of FIG.21A.

FIG. 22A is a perspective view of the side of a boosting cathetershowing the junction of the proximal and distal portions, according toone implementation.

FIG. 22B is a perspective view of the top of the boosting catheter ofFIG. 22A.

FIG. 22C is a perspective view of the underside of the boosting catheterof FIG. 22A.

DETAILED DESCRIPTION

The various embodiments disclosed and contemplated herein relate to aboosting catheter that is adapted to be positioned through and extenddistally from a conventional guiding catheter, wherein the guidingcatheter is adapted to extend into a patient.

The various boosting catheter embodiments disclosed herein have a distaltubular portion adapted to extend through and beyond the distal end ofthe guiding catheter. The embodiments also include a proximal elongatedshaft connected to the tubular portion at a junction. In certainimplementations, the elongated shaft defines a lumen therein (that is,the shaft is hollow or has a hollow-body construction that defines alumen). The lumen can be configured to conduct fluid along the shafttowards or through the tubular portion or simply to enhance thetrackability and passage performance. According to some embodiments, theshaft defines an opening disposed within or in fluid communication withthe lumen of the distal tube such that fluid leaving the opening canflow through the tube.

In addition to serving as a conduit for fluids in certainimplementations, a manipulation shaft with at least one lumen can haveenhanced flexibility both in the axial direction and the longitudinal(or circumferential) direction. This configuration can further enhancethe advancement characteristics of the catheter as well as passage ofother devices through the guiding catheter (and alongside themanipulation shaft). In addition, the manipulation shaft with the lumencan exhibit a greater propensity to conform to the inner diameter of theguiding catheter, thereby allowing more flexibility and allow enhancedpassage of devices within the guiding catheter in the zones occupied bythe manipulation shaft.

FIG. 1 depicts a conventional guiding catheter 12 being used in thegeneral operating environment, which is partially within a human body,and usually within an artery or vein. As shown in the figure, theguiding catheter 12 may be inserted into the vasculature through anumber of different access points in the body. For example, a femoralartery approach is shown at A, while a radial artery approach is shownat B. Further, other parts of the vasculature may be accessed withvarious guiding catheters or sheaths. For example, at C, a sheath isshown inserted through the femoral artery for a contralateral approachfor procedures in the leg or other parts of the body. In anotherexample, the sheath is inserted through the femoral artery to access therenal arteries in one of the kidneys at D. Regardless of the accesspoint or the target portion of the vasculature, the various boostingcathether implementations disclosed herein can be used in combinationwith guiding catheters or sheaths to assist with various procedures. Forexample, the boosting catheter embodiments in combination with guidingcatheters or sheaths can be used to assist with the passage of otherinterventional, diagnostic, or therapeutic devices to various locationsin the vasculature. In other instances, the various implementations canbe used in combination with guiding catheters or sheaths to assist withthe transmission of contrast, diagnostic, or therapeutic fluids/agentsby injecting the fluids/agents through the boosting catheter to variouslocations, or by transmitting the fluids/agents through the guidingcatheter via a hemostasis valve and subsequently passing it through thedistal tube of the boosting catheter. In another example, the boostingcatheter embodiments in combination with guiding catheters or sheathscan be used to assist with the removal of thrombus, emboli, or debrispresent in the vasculature through the guiding catheter/sheath byapplying a vacuum at the proximal end of the guiding catheter/sheath.

As shown in FIG. 2A, various embodiments of a boosting catheter(generally shown at 10) as disclosed and contemplated here can be usedin conjunction with any conventional guiding catheter 12 for purposes ofthe various procedures described above. As shown in FIG. 2A, the distalend of the boosting catheter 10 is positioned through and extendeddistally from the distal end of the conventional guiding catheter 12.

Certain examples of boosting catheters 10 according to variousembodiments are shown in further detail in FIGS. 2B, 3A, 3B, and 3C.Each boosting catheter implementation 10 has two basic parts: a distalportion that is a comparatively large diameter tube (generally indicatedat 14) defining a lumen 36; and a proximal portion that is acomparatively smaller diameter elongate member such as a tube or rod,also referred to herein as a “manipulation shaft” (generally indicatedat 16). In certain embodiments, as best shown in FIGS. 3A-3C, themanipulation shaft defines at least one lumen 38 along the length of theshaft 16. Alternatively, the proximal portion 16 is a solid wire or railthat is not hollow. The one or more lumens 38 defined within themanipulation shaft 16 can extend to the proximal portion of the tubularshaft 14. The lumen(s) 38 can also extend through or alongside the lumen36 of the tubular shaft 14 and exit at the very distal end of the shaft14 or somewhere in between. The lumen 38 may also extend beyond thetubular shaft 14. According to certain embodiments as will be describedin further detail below, the one or more lumens 38 are configured toreceive a fluid (such as, for example, a contrast solution) such thatthe fluid can be urged from the proximal end of the lumen 38 to thedistal end of the lumen 38 and thereby dispense or deliver the fluid outof the distal end of the shaft 16.

The larger diameter tube 14 is, according to one embodiment, madegenerally from flexible polymeric materials. The tube 14 can have, inone specific example, a PEBAX, polyurethane, or NYLON outer layer, and aPTFE inner layer. The tube 14 may also incorporate re-enforcing coil ormesh. The tube 14 may also incorporate radiopaque markers (such asmarkers 24, 26, or 28 as discussed below) on the tube 14. Themanipulation shaft 16 may also incorporate one or more visual markers,including radiopaque markers.

As shown in FIGS. 3A, 3B, and 3C, certain embodiments of the largerdiameter tube 14 can have three segments or more of differingflexibilities: low flexibility at the proximal end 18 of the tube 14,medium flexibility in the middle 20 of the tube 14, and high flexibilityat the distal end 22. More segments of varying flexibilities can also beused. In fact, the transition zone 40 (the area of overlap in which themanipulation shaft 16 is coupled to the larger tube 14) has varyingflexibility in that zone 40. The differing flexibilities can beaccomplished through combinations of differing materials,configurations, or geometries—as is known in the art (e.g. mesh or coilreinforcing, different PEBAX varieties, etc.). Moreover, differentlengths can be selected for the segments 18, 20, 22 and the transitionzone 40 according to design considerations. For example, if the smallerdiameter shaft 16 has at least one lumen 38, then the low flexibilitysegment 18 may be longer to obtain optimal advancement characteristics.This permits more flexibility along a greater length of the boostingcatheter 10 as needed to deal with anticipated curvature in the path thecatheter 10 must follow. An example of this is illustrated in FIG. 2B,which shows the smaller diameter tube 16 terminating where anticipatedcurves begin.

As mentioned above, the flexible tube 14 can have radiopaque markers.embedded in the tube 14 and placed along the length of the tube 14 forvarious purposes. For example, marker 24 can be used at or near thedistal tip 42 of the tube 14 to help the doctor locate the position ofthe tip 42. Another marker 26 could be used at or near the proximal end44 of the tube 14 to assist the doctor in locating that end 44 of thetube 14 relative to the end of the guiding catheter or to assist invisualizing the location of the proximal opening of the tube 14. In oneembodiment, the marker band 26 can be located near the proximal end 44of the tube but at a position on the tube 14 that is distal to the end44, as shown in FIGS. 3A-3C.

Further, in certain embodiments, a radiopaque marker (not shown) can belocated anywhere in or near the transition zone 40 (e.g. on themanipulation shaft 16 in or near the transition zone 40 or in the distaltube 14 in the transition zone 40). Further, any of the markers 24, 26,28 can be non-cylindrical. For example, one or more of the markers 24,26, 28 can be strips or other known configurations.

One or more of these markers 24, 26, 28 can be helpful to indicate tothe doctor or surgeon the location of the proximal end 44 of the tube 14in relation to the guiding catheter (such as catheter 12) so that theydo not insert or push the proximal end 44 past the distal end of theguiding catheter 12. In this regard, certain embodiments include a thirdmarker 28 located at some optimal point along the tube 14 in between theother two markers 24 and 26, as shown in FIGS. 2B, 3B, and 3C. As shownbest in FIG. 2B, the doctor or surgeon can use this third marker 28 totrack how far the tube 14 is extending beyond the guiding catheter 12.That is, the third marker 28 can be used in certain circumstances as alimit indicator. For example, in a specific embodiment having a tube 14that is 35 cm in length, the third marker band 28 may be located 15 cmfrom the distal end 42 of the tube 14 in order to indicate thispredetermined distance to the doctor, such that the doctor knows thedistance that the distal end 42 extends beyond the guide catheter 12.Depending on the specific configuration of the boosting catheter 10, thethird marker band 28 can be disposed in the low flexibility segment 18,the middle flexibility segment 20, or possibly even in the highflexibility segment 22.

It is understood that the distal tube 14 can have one, two, three, ormore markers as described above. It is further understood that anymarker arrangement of one or more markers, including the three markerarrangement, can be used in connection with a variety of boostingcatheter configurations, including those having a solid rail (e.g. aflat or round wire) or a hollow rail or proximal section with a lumen,such as a tube. In other implementations, one or more markers can bepositioned on the shaft 16.

In one implementation, the proximal portion 16 is an elongate member 16(such as a tube) having a lumen defined therein, wherein the elongatemember 16 is made of at least one metal and/or at least one polymer. Oneexample of a metal that can be used is stainless steel, such as 304 or316 grade stainless steel. According to certain embodiments, the tube 16can be coated (for additional lubricity, for example) with one or morematerials such as TEFLON or PTFE, or with another hydrophilic coating,or a hydrophobic coating (like silicone). The tube can also be made fromnitinol (nickel-titanium) for improved kink resistance.

In certain embodiments, the manipulation shaft 16 is coupled to thedistal tube 14 such that the shaft 16 and the lumen 38 defined in theshaft 16 extend into or through the distal tube 14. Various shaft 16configurations can be used for this purpose. For example, FIGS. 4A-4Cdepict a distal portion of a manipulation shaft 16 having a fulldiameter section 46 and a reduced diameter section 48 at the distal endof the shaft 16. FIG. 4A depicts a side view of the shaft 16, while FIG.4B shows a front view of shaft 16 and FIG. 4C provides a top view of theshaft 16. As best shown in FIGS. 4B and 4C, the reduced diameter section48 has a substantially ovular cross-section, while the full diametersection 46 has a substantially circular cross-section. As best shown inFIG. 4A, the lumen 38 of the shaft 16 extends through both the fulldiameter 46 and reduced diameter 48 sections.

Certain embodiments, including the embodiment shown at FIGS. 4A-4C, areconfigured to be capable of dispersing fluids through the shaft 16,including fluids such as contrast solution, saline solution, ortherapeutic solutions. For example, the shaft 16 in FIGS. 4A-4C has alumen 38 and a distal opening 50 configured to allow for fluids to passthrough the lumen 38 and be dispersed out of the opening 50. Further,the reduced diameter section 48 with the lumen 38 is configured to becoupled to the distal tube 14 such that a distal portion of the reduceddiameter section 48 is integrated into a proximal portion of the tube 14in the transition zone (such as transition zone 40) as discussed infurther detail below. Alternatively, the reduced diameter section 48with the lumen 38 need not be used to transfer or disperse fluids andinstead can simply be configured to be coupled to the distal tube 14 asdisclosed herein. In such embodiments as will be described in furtherdetail below, the lumen 38 is configured to have a distal opening (suchas distal opening 50 discussed above) that places the lumen 38 in fluidcommunication with either the lumen 36 of the distal tube 14 or anexterior area of the distal tube 14. Alternatively, the manipulationshaft 16 can be configured to have no distal opening and thus have alumen that is not in fluid communication with the distal tube 14 oranything else at its distal end.

There can be benefits of a proximal portion having a lumen. As discussedabove, it allows for transmission of fluid through a conduit that issmaller in diameter than the guiding catheter. In certain embodiments,the lumen is sized specifically to conduct the desired amount of aspecific fluid into the distal tube, into a wall of the distal tube, outof the wall of the distal tube through an opening somewhere along thelength of the tube, or out of the distal end of the distal tube. Thecontrol of the lumen size can allow for transmission of more or lessfluid, depending on what is desired. For example, less fluid can bedesirable when the fluid is contrast solution that is typically used inseveral catheter-based procedures, because greater amounts of contrastsolution can cause harm to the patient.

Additional configurations of the distal end of the manipulation shaft 16are shown in FIGS. 5 and 6. In the embodiment shown in FIG. 5, thetransition section 52 between the full diameter section 46 and thereduced diameter section 48 involves a narrowing around the fullcircumference of the shaft 16 as shown (in contrast to a narrowing ofone portion of the shaft 16 as shown in FIG. 4A). Alternatively, FIG. 6depicts a shaft 16 having an extended tapered section 47 from the fulldiameter section 46 to the reduced diameter section 48.

The various manipulation shaft 16 embodiments as discussed in furtherdetail elsewhere herein provide for a gradual change in flexibility fromthe proximal end of the shaft 16 to the the distal end. Further, certainshaft implementations are configured such that the distal portion of theshaft 16 couples with the tube 14 in such a way as to maximize the innerdiameter (the lumen 36) of the tube 14. That is, in certainimplementations, the various boosting catheters 10 disclosed orcontemplated herein require a sufficiently accessible opening 44 (asbest shown in FIGS. 3A-3C) at the proximal end of the distal tube 14 toallow for the lumen 36 to be accessible for medical devices. In otherwords, the opening 44 must be large enough and/or have sufficientclearance to allow for easy insertion of various medical devices intothe opening 44 such that the devices can be urged distally through thetube 14 and out of the opening at the distal end 42 of the tube 14. Incertain of these embodiments, clearance at the opening at the proximalend 44 of the distal tube 14 can be optimized by minimizing the profile(by reducing the diameter, etc.) of the manipulation shaft 16 accordingto various configurations as disclosed herein.

As mentioned above, in accordance with some embodiments, the distalportion of the manipulation shaft 16 is integrated or embedded in theproximal end of the distal tube 14. For example, in certainimplementations, the distal tube 14 is molded over the distal end of themanipulation shaft 16, thereby creating a transition zone such as thezone 40 discussed above.

In certain embodiments, the distal end of the manipulation shaft 16 maybe coupled to the distal tube 14 in an eccentric manner, rather than aconcentric manner. That is, the shaft 16 is joined to the distal tube 14at one point or in one zone of the periphery or circumference of thedistal tube 14 (“eccentrically”), rather than being joined togetheraround the entire circumference of the shaft 16 and tube 14. Forexample, in one implementation as shown in FIGS. 7A-7C, the manipulationshaft 16 is coupled to the distal tube 14 at a point or area of the wall56 of the tube 14. The shaft 16 in this embodiment is made up of tworods 54A, 54B positioned within the lumen 38 of the shaft 16, as bestshown in FIG. 7C. In one embodiment, the rods 54A, 54B are solid (thatis, they do not have lumens). Alternatively, the rods 54A, 54B can behypotubes 54A, 54B, with each having a lumen defined therein. As bestshown in FIGS. 7A and 7B, a distal portion of the shaft 16 is coupled toand integral with an outer wall 56 of the distal tube 14 at thetransition zone 40. Further, as best shown in FIG. 7A, the two rods 54A,54B extend from the distal portion of the shaft 16 such that the distalportions 58A, 58B of the rods 54A, 54B extend into the distal tube 14.More specifically, the distal portion 58A of rod 54A is disposed in thewall 56 of the distal tube 14 at a position that is on the opposite sideof the wall 56 across the lumen 36 from the distal portion 58B. Further,as best shown in FIG. 7B, both distal portions 58A, 58B (only 58B isvisible in FIG. 7B because of the location of distal portion 58A behinddistal portion 58B in the figure) extend at an angle toward a verticalmidpoint of the tube 14 and extend horizontally along that position forsome distance as well as shown. In accordance with one implementation,the positioning of the distal portions 58A, 58B of the rods 54A, 54B inthe wall 56 of the distal tube 14 enhances the kink resistance of thatportion of the tube 14 as well as assisting in transmitting a distal orproximal force to the distal tube 14 in a more even fashion during useof the catheter 10.

Additional embodiments of manipulation shafts 16 coupled to distal tubes14 are shown in FIGS. 8A-10. The device 10 depicted in FIGS. 8A and 8Bhas a manipulation shaft 16 coupled to the distal tube 14 such that adistal portion of the manipulation shaft 16 is positioned within thelumen 36 of the tube 14 or integrated into an outer wall 56 in thetransition zone 40 of the tube 14. In this embodiment, the taperedportion 47 of the shaft 16 is a taper along one side of the shaft 16such that the tapered portion 47 is an angled portion 47 on the side ofthe shaft 16 opposite the lumen 36 of tube 14. Hence, the opening 50 atthe distal end of the shaft 16 is along the tapered portion 47 of thedistal end of the shaft 16 such that the opening 50 faces away from thelumen 36 of the tube 14. In this specific embodiment as best shown inFIG. 8B, the opening 50 is actually made up of multiple openings 50defined along the tapered portion 47 of the shaft 16 and outer wall 56of the distal tube in fluid communication with the lumen 38.Alternatively, the opening 50 can be a single opening, two openings, orany number of openings. In this exemplary implementation, the lumen38—via the openings 50 in the shaft 16 and wall 56—is in fluidcommunication with an area or space outside the distal tube 14.Alternatively, the openings 50 can be on the side of the shaft 16 facingthe lumen 36 of tube 14 such that the lumen 38 is in fluid communicationwith the lumen 36 of tube 14. In a further embodiment, the shaft 16 hasno opening at the distal end of the shaft 16 and thus, while the distalend of the shaft 16 is positioned within the distal tube 14 or someportion thereof, the lumen 38 is not in fluid communication with thedistal tube 14 or any portion thereof.

The device 10 shown in FIG. 9 has a manipulation shaft 16 coupled to thedistal tube 14 such that a distal portion of the manipulation shaft 16is positioned within the lumen 36 of the tube 14 or integrated into anouter wall 56 in the transition zone 40 of the tube 14. In thisembodiment, the transition section 52 from the full diameter section 46to the reduced diameter section 48 of the shaft 16 is a taper around theentire circumference of the shaft 16 as shown. In this embodiment, thetransition section 52 is positioned outside the lumen 36 (or the outerwall 56) of the distal tube 14, and the opening 50 at the distal end ofthe shaft is positioned within the lumen 36. In this exemplaryimplementation, the opening 50 is in direct fluid communication with thelumen 36 of tube 14 or is integrated into the outer wall 56 and is influid communication with the lumen 36 via an opening in the wall 56 ofthe tube 14.

The device 10 shown in FIG. 10 has a manipulation shaft 16 coupled tothe distal tube 14 such that a distal portion of the manipulation shaft16 is positioned within the lumen 36 of the tube 14 or integrated intoan outer wall 56 in the transition zone 40 of the tube 14. In thisembodiment, the transition section 52 of the shaft 16 is a taper 52around the entire circumference of the shaft 16 as shown. In thisembodiment, the transition section 52 is positioned within the lumen 36(or the outer wall 56) of the distal tube 14 such that the entirereduced diameter section 48 is positioned within the lumen 36 (or theouter wall 56). In this exemplary implementation, the opening 50 is indirect fluid communication with the lumen 36 of tube 14 or is integratedinto the outer wall 56 and is in fluid communication with the lumen 36via an opening in the wall 56 of the tube 14. Alternatively, the lumen38 of the shaft 16 is not in fluid communication with the lumen 36 oftube 14.

It is understood that the manipulation shaft 16 in these embodiments ofFIGS. 8-10 can have a single lumen 38. Alternatively, the shaft 16 ofany of the three embodiments can have a lumen 38 containing one or twoelongate members in a fashion similar to the shaft 16 described abovewith respect to FIGS. 7A-7C. In another alternative, the shaft 16 can beconfigured in any fashion as described elsewhere herein.

The device 10 shown in FIG. 11 has a manipulation shaft 16 coupled tothe distal tube 14 such that a distal portion of the manipulation shaft16 is positioned within the lumen 36 of the tube 14 or integrated intoan outer wall 56 in the transition zone 40 of the tube 14. In thisembodiment, the reinforcing coil 62 of the tube 14 extends proximallyinto the transition zone 40 and has a larger pitch in the transitionzone 40. That is, the separate strands of the coil 62 are farther apartin the transition zone 40. According to one embodiment, this largerpitch results in lesser reinforcement or support by the coil 62 in thatarea of the tube 14. In certain embodiments, this is because the distalportion of the shaft 16 in the transition zone 40 provides additionalsupport or reinforcement.

The device 10 shown in FIG. 12 has a manipulation shaft 16 coupled tothe distal tube 14 such that a distal portion of the manipulation shaft16 is positioned within the lumen 36 of the tube 14 or integrated intoan outer wall 56 in the transition zone 40 of the tube 14. In thisembodiment, the distal portion of the shaft 16 has no tapered portionand extends along the entire length of the distal tube 14 such that theopening 50 of the shaft 16 is positioned at the opening in the distalend 42 of the tube 14. Alternatively, the shaft 16 can extend distallyout of the opening at the distal end 42 of the tube 14.

As discussed above, certain implementations of the proximal shaft 16have a tube defining a lumen in which two separate inner elongatemembers are positioned. For example, the manipulation shaft 16 shown inFIG. 13 has an outer tube 80 defining a lumen 82 with two inner elongatemembers 84A, 84B positioned therein. The shaft 16 has a reduced diameterportion 48 in which both of the elongate members 84A, 84B have reduceddiameter portions 86A, 86B as shown. In this exemplary embodiment, eachelongate member 84A, 84B has a transition section 52A, 52B between thefull diameter section 46A, 46B and the reduced diameter section 48A, 48Bthat involves a narrowing around the full circumference of the members84A, 84B as shown.

Alternatively, the manipulation shaft 16 shown in FIG. 14 has an outertube 80 defining a lumen 82 with two inner elongate members 84A, 84Bpositioned therein. The shaft 16 has a tapered section 47 in which bothof the elongate members 84A, 84B have tapered sections 47A, 47B asshown. In this exemplary embodiment, each elongate member 84A, 84B hasan extended taper from the full diameter section 46A, 46B to the reduceddiameter section 48A, 48B.

As mentioned above with respect to certain specific embodiments, thecross-sectional configuration of the manipulation shaft 16 can take anynumber of different forms. For example, FIGS. 15A and 15B depictcross-sectional configurations of different manipulation shaft 16embodiments. FIG. 15A depicts a shaft 16 comprised of an elongate member16 having a metal body 100 with a square or parallelogram-shapedcross-section and a polymeric outer coating 80. The metal body 100defines a lumen 102 in the body 100 that runs along the entire length ofthe body 100.

In an alternative configuration as shown in FIG. 15B, the shaft 16 hasan elongate member 16 with a metal body 100 having a square orparallelogram-shaped cross-section and a polymeric outer coating 80. Inaddition, the metal body 100 defines a lumen 102 in the body 100 thatruns along the entire length of the body 100. Further, a tube 104 isprovided that is positioned within the lumen 102 in the body 100. Thetube 104 can be made of metal or a polymeric material. In a furtherembodiment, the tube 104 is a polymeric coating 104 that is configuredto line the lumen 102.

FIG. 16A depicts the cross-section of the manipulation shaft 16according to another embodiment in which the shaft 16 is a hollow tube16 with a circular cross-section. FIG. 16B depicts a shaft 16 that is ahollow tube 16 with a relatively square cross-section. FIG. 16C shows ashaft 16 that is a hollow tube 16 with a relatively rectangularcross-section. FIG. 16D depicts a shaft 16 that is a hollow tube with arelatively ovular cross-section. FIG. 16E shows a shaft 16 that is ahollow tube 16 with a relatively kidney bean-shaped cross-section. Theshaft 16 in FIG. 16F is an elongate member 16 with a lumen 82 in whichtwo smaller, hollow elongate members 84A, 84B are disposed. FIG. 16Gdepicts an elongate member 16 with a lumen 82 in which two smaller,solid (non-hollow) elongate members 84A, 84B are disposed. FIG. 16Hshows an elongate member 16 having a substantially ovular cross-sectionwith a lumen 82 in which a single smaller elongate member 84 isdisposed. FIG. 16I depicts an elongate member 16 with a lumen 82 inwhich two smaller, solid (non-hollow) elongate members 84A, 84B and athird smaller hollow elongate member 84C are disposed.

With respect to the shafts 16 shown in FIGS. 16F, 16G, 16H, and 16I, theadditional smaller elongate members 84A, 84B, 84C disposed within thelumen 82 of the shaft 16 add support or reinforcement to the shaft 16while also having multiple lumens within the shaft 16. For example, theshaft 16 in FIG. 16F has two lumens 88A, 88B in the two elongate members84A, 84B, along with two lumens 82A, 82B created in the spaces on eitherside of the two elongate members 84A, 84B. Similarly, it should be notedthat the shaft 16 configurations described above and depicted in FIGS.7A-7C, 13, and 14 have similar configurations that also have lumens inthe spaces created by the elongate members disposed therein. The shaft16 in FIG. 16G has two lumens 82A, 82B created in the spaces on eitherside of the two solid (non-hollow) elongate members 84A, 84B. In FIG.16H, the shaft 16 has a single larger lumen 82 defined by the shaft 16with the single elongate member 84 disposed therein. In FIG. 16I, theshaft 16 has a lumen 88 within the hollow elongate member 84C and twolumens 82A, 82B in the spaces on either side of the member 84C. Further,it is understood that any of these configurations as shown in FIGS.16A-16I can be any combination or number of solid and/or hollow elongatemembers.

In some embodiments, the elongate members 84A, 84B, 84C are slideablydisposed within the shaft 16, such that the elongate members 84A, 84B,84C are slideable in relation to the shaft 16 and each other.Alternatively, the elongate members 84A, 84B, 84C are joined, bonded, orotherwise coupled to each other such that they are not slidable inrelation to each other. In a further implementation, the elongatemembers 84A, 84B, 84C can be coupled or otherwise joined to each otherand to the shaft 16 such that they are not slideable in relation to eachother or the shaft 16.

According to various embodiments, the manipulation shaft 16 can have adiameter that ranges from about 0.01 inches to about 0.03 inches (or canhave a size that ranges from about ¼ French to about 3 French). Thevarious inner elongate members can be made of stainless steel, nitinol,or other similar metals. In those embodiments with inner elongatemembers, the outer wall of the shaft 16 is made of polymeric materialssuch as PET, PTFE, Teflon, FEP, PE, PEBA, or other similar materials.

As shown in FIGS. 2B and 17A, the manipulation shaft 16 can terminate ina proximal fitting 32. In accordance with one embodiment, the fitting 32is adapted for connection to a fluid source. In certain embodiments, thefitting 32 is a standard female luer connection that is made fromplastic. The fitting 32 can be bonded to the manipulation shaft 16 withadhesive, or it can be insert-molded over the manipulation shaft 16. Inthe embodiment shown in FIG. 17A, there is an optional strain-reliefsegment 34 disposed between the manipulation shaft 16 and the proximalfitting 32. The strain relief segment 34 provides a flexible transitionfrom the manipulation shaft 16 to the proximal fitting 32.

Alternatively, in FIG. 17B, the proximal end of the lumen 38 in theshaft 16 does not have an opening. That is, the proximal end of thelumen 38 is not in fluid communication with any opening at the proximalend of the shaft 16.

Other device 10 embodiments include additional support structure in thedistal tube 14 that can provide mechanical advantage similar to thatprovided by the support coil. FIG. 18A depicts a device 10 having adistal tube 14 with a support member 110 positioned in the transitionzone 40 that is configured to assume at least some of the mechanicalloads. Alternatively, FIG. 18B depicts another embodiment of a supportmember 110 positioned in the transition zone 40 of a distal tube 14,while FIG. 18C shows a further implementation of a support member 110.In a further alternative, the tube 14 can have two or more supportmembers. In certain embodiments, the support member (including thesupport members 110 depicted in FIGS. 18A-18C) can be the distal portionof the rod or tube extending distally from the shaft 16.

In use, the device 10 according to any of the embodiments disclosedherein can be used to conduct a predetermined amount of contrastsolution (or any other fluid that could be used in this context asdescribed above) from a reservoir in an operating room into a human bodyto a predetermined location. In one embodiment, the method can involvethe steps of: introducing a guiding catheter into a human body along apredetermined pathway to a predetermined location; inserting theboosting catheter 10 into the guiding catheter, where the boostingcatheter 10 includes the proximal portion 16 and the distal portion 14,and moving it distally along the guiding catheter a predetermineddistance; introducing the solution into the proximal end of the proximalportion; conducting the fluid along the length of the proximal portion16; and dispersing the solution distal of the proximal portion 16 intothe human body in order to make the portion of the body (typically anartery or vein) visible to a doctor using an x-ray or similar device. Itis further understood that any of the device implementations disclosedor contemplated herein can be used to perform any of the proceduresdescribed above with respect to FIG. 1.

Alternative manipulation shaft 16 embodiments are shown in FIGS.19A-19D″. These various shaft 16 embodiments have various openingconfigurations, including gradual tapered sections or tapered sections,including some such sections at the distal opening, at the distal end ofthe shaft 16. In certain implementations, the tapered section can becreated via cutting or grinding processes. Alternatively, any knownprocess for creating such a tapered configuration can be used.

FIGS. 19A and 19A′ show a shaft 16 having a a shallow tapered section 47and a straight extension 120. FIG. 19B depicts a shaft 16 having atapered section 47 without a straight extension. FIG. 19C shows a shaft16 with a curved tapered section 47. FIG. 19D shows a shaft 16 with adistal end that is perpendicular to the longitudinal axis of the shaft16, and a short segment of flat wire 122 can be coupled to it, such asin a slot joint 124 (FIG. 6D′) or a lap joint 126 (FIG. 6D″).

As shown in FIG. 20A, the proximal end 44 of the distal tube 14 may beconfigured so that the opening 130 is perpendicular to the axis of thetube 14. In other embodiments, the opening 130 can be tapered, as shownin FIG. 20B; or the opening 130 may be flared, as shown in FIG. 7C.Still further, the opening 130 may be extended with an axially-extendingslit 30 in the wall of the tube, as shown in FIG. 20A. In these latterthree embodiments, the purpose of the enlarged opening 130 (and the slit30) is to facilitate movement of tools and medical devices along theaxis of the boosting guide catheter.

In a further implementation as shown in FIG. 20D, the proximal end ofthe distal tube 14 has one or more holes 132, slots, or any kind ofopenings defined in the wall of the tube 14. In the specific exampledepicted, the tube 14 has three slots 132, each of which has a long sidethat is perpendicular with the longitudinal axis of the tube 14.Alternatively, the tube 14 can have less than three or more than threeholes. In accordance with certain embodiments, the one or more openings132 can act as hinge-like components that allows for flexure of theproximal end of the tube 14 while minimizing or preventing bucklingthereof.

According to a further embodiment depicted in FIGS. 21A and 21B, thedevice 140 has a manipulation shaft 16 that is made up of two rods 54A,54B positioned within the lumen 38 of the shaft 16 (as best shown inFIG. 21B). FIG. 21A is a side view, while FIG. 21B is a top view. Inthis implementation, the shaft 16 is a polymeric coating 16 such aspolyester and/or PET. A distal portion of the shaft 16 is coupled to andintegral with an outer wall 56 of the distal tube 14 at the transitionzone 40. Further, the two rods 54A, 54B extend from the distal portionof the shaft 16 such that the distal portions 58A, 58B of the rods 54A,54B extend into the distal tube 14. More specifically, the distalportion 58A of rod 54A is disposed in the wall 56 of the distal tube 14at a position that is on the opposite side of the wall 56 across thelumen 36 from the distal portion 58B. Further, as best shown in FIG.21A, both distal portions 58A, 58B (only 58B is visible in FIG. 21Abecause of the location of distal portion 58A behind distal portion 58Bin the figure) extend at an angle toward a vertical midpoint of the tube14 and extend horizontally along that position for some distance as wellas shown. In this specific implementation, both of the distal portions58A, 58B of the rods 54A, 54B have a flat configuration, therebyreducing their profiles within the distal tube 14. In addition, in thisimplementation, a tube 142 is positioned between the two rods 54A, 54B,with the proximal end of the tube 142 extending into the shaft 16 andthe distal end extending into the distal tube 14 as shown. It isunderstood that the proximal end of the tube 142 can be positioned atany point along the length of the manipulation shaft 16. Alternatively,the proximal end of the tube 142 can extend to the proximal end of themanipulation shaft 16. According to one embodiment, the tube 142 has alumen (not shown) in fluid communication with the lumen 38 of themanipulation shaft 16 and further in fluid communication with the lumen36 of the distal tube. Alternatively, the tube 142 can have a lumen (notshown) that is not in fluid communication with the lumen 38 or the lumen36. In yet another alternative, the tube 142 has no lumen. Further, inthis embodiment, two marker bands 144 are positioned around the rods54A, 54B.

FIGS. 22A, 22B, and 22C depict another device 150 having a manipulationshaft 16 that is made up of two rods 54A, 54B positioned within thelumen 38 of the shaft 16. FIG. 22A is a side view, while FIG. 22B is atop view and FIG. 22C is an underside view. As in the embodiment shownin FIGS. 21A and 21B, the two rods 54A, 54B extend into the distal tube14. Further, the two distal portions 58A, 58B have a flat configurationas shown. The distal portion 58A is disposed in the wall 56 of thedistal tube 14 at a position that is on the opposite side of the wall 56across the lumen 36 from the distal portion 58B. Further, as best shownin FIG. 22A, both distal portions 58A, 58B (only 58B is visible in FIG.22A because of the location of distal portion 58A behind distal portion58B in the figure) extend at an angle toward a vertical midpoint of thetube 14 and extend horizontally along that position for some distance aswell as shown. Unlike the prior embodiment (in FIGS. 21A and B), thisimplementation has no additional tube disposed between the two rods 58A,58B.

What is claimed is:
 1. A boosting catheter comprising: (a) a distal tubecomprising: (i) a tubular wall; (ii) a tube lumen defined within thetube by the tubular wall; (iii) a proximal opening in fluidiccommunication with the tube lumen, wherein the proximal opening is sizedto allow a medical device to be positioned therethough; and (iv) atleast one opening defined within the tubular wall along a length of thedistal tube, wherein the at least one opening is in fluidiccommunication with the tube lumen; and (b) a proximal shaft operablycoupled to a proximal portion of the distal tube.
 2. The boostingcatheter of claim 1, wherein the at least one opening is defined withinthe tubular wall such that the tube lumen is in fluidic communicationwith an area external to the distal tube.
 3. The boosting catheter ofclaim 1, further comprising a visual marker disposed on the distal tubeor the proximal shaft.
 4. The boosting catheter of claim 3, wherein thevisual marker is a radiopaque marker.
 5. The boosting catheter of claim1, wherein the at least one opening comprises at least two openings. 6.The boosting catheter of claim 1, wherein the proximal shaft comprisesat least one shaft lumen defined in the proximal shaft.
 7. The boostingcatheter of claim 5, further comprising at least one elongate memberdisposed within the at least one shaft lumen.
 8. A boosting cathetercomprising: (a) a distal tube comprising: (i) a tubular wall; (ii) atube lumen defined within the tube by the tubular wall; (iii) a proximalopening in fluidic communication with the tube lumen, wherein theproximal opening is sized to allow a medical device to be positionedtherethough; and (iv) at least two openings defined within the tubularwall along a length of the distal tube, wherein the at least twoopenings are in fluidic communication with the tube lumen; and (b) aproximal shaft operably coupled to a proximal portion of the distaltube, the proximal shaft comprising at least one shaft lumen defined inthe proximal shaft.
 9. The boosting catheter of claim 8, wherein the atleast two openings are defined within the tubular wall such that thetube lumen is in fluidic communication with an area external to thedistal tube.
 10. The boosting catheter of claim 8, further comprising avisual marker disposed on the distal tube or the proximal shaft.
 11. Theboosting catheter of claim 10, wherein the visual marker is a radiopaquemarker.
 12. The boosting catheter of claim 8, further comprising atleast one elongate member disposed within the at least one shaft lumen.13. The boosting catheter of claim 12, wherein the at least one elongatemember defines a lumen therein.
 14. The boosting catheter of claim 8,wherein the proximal shaft is configured to extend into a portion of thedistal tube such that the shaft lumen extends distally past a proximalend of the distal tube.
 15. A boosting catheter comprising: (a) a distaltube comprising: (i) a tubular wall; (ii) a tube lumen defined withinthe tube by the tubular wall; (iii) a proximal opening in fluidiccommunication with the tube lumen, wherein the proximal opening is sizedto allow a medical device to be positioned therethough; and (iv) aplurality of openings defined within the tubular wall along a length ofthe distal tube, wherein the plurality of openings are in fluidiccommunication with the tube lumen such that the tube lumen is in fluidiccommunication with an area external to the distal tube; and (b) aproximal shaft operably coupled to a proximal portion of the distaltube, wherein the proximal shaft is configured to extend into a portionof the distal tube such that the shaft lumen extends distally past aproximal end of the distal tube, the proximal shaft comprising a shaftlumen defined in the proximal shaft.
 16. The boosting catheter of claim15, wherein the proximal shaft further comprises: (i) a first elongatemember disposed within the shaft lumen; and (ii) a second elongatemember disposed within the shaft lumen.
 17. The boosting catheter ofclaim 16, wherein at least one of the first and second elongate membersdefines a lumen therein.
 18. The boosting catheter of claim 16, whereinat least one of the first and second elongate members has no lumen. 19.The boosting catheter of claim 15, wherein the proximal shaft furthercomprises a tube disposed in the proximal shaft.
 20. The boostingcatheter of claim 15, further comprising a visual marker disposed on thedistal tube or the proximal shaft.